2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-154119
    3’-Azido-3’-deoxy-6-azauridine
    3’-Azido-3’-deoxy-6-azauridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 3’-Azido-3’-deoxy-6-azauridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    3’-Azido-3’-deoxy-6-azauridine
  • HY-154029
    3-β-D-Ribofuranosyl-6-hydroxymethyl-furano[2,3-d]-pyrimidin-2-one
    3-β-D-Ribofuranosyl-6-hydroxymethyl-furano[2,3-d]-pyrimidin-2-one is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3-β-D-Ribofuranosyl-6-hydroxymethyl-furano[2,3-d]-pyrimidin-2-one
  • HY-W565157
    3,5-O-Ditoluoyl 6-chloropurine-9-β-D-deoxyriboside
    3,5-O-Ditoluoyl 6-chloropurine-9-β-D-deoxyriboside is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3,5-O-Ditoluoyl 6-chloropurine-9-β-D-deoxyriboside
  • HY-112582S
    N1-Methylpseudouridine-d3
    N1-Methylpseudouridine-d3 is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    N1-Methylpseudouridine-d<sub>3</sub>
  • HY-154222
    5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite
    		98.0%
    5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    5’-O-DMTr-2’,2’-difluoro-dC(Bz)-3’-CED-phosphoramidite
  • HY-180771
    4-Hydroxy-2-oxopentanoic acid
    4-Hydroxy-2-oxopentanoic acid is a nucleoside metabolite.
    4-Hydroxy-2-oxopentanoic acid
  • HY-154346
    5’-Azido-5’-deoxy-5-methyluridine
    5’-Azido-5’-deoxy-5-methyluridine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc. 5’-Azido-5’-deoxy-5-methyluridine is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
    5’-Azido-5’-deoxy-5-methyluridine
  • HY-180638
    3-Indoleglycolaldehyde
    3-Indoleglycolaldehyde, a bacterial metabolite, is a plant growth promoter.
    3-Indoleglycolaldehyde
  • HY-154621
    3’-O-Hexadecanyl adenosine
    3’-O-Hexadecanyl adenosine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    3’-O-Hexadecanyl adenosine
  • HY-145981
    m7GpppCpG
    m7GpppCpG, an oligonucleotide, is an M7GpppNpG trinucleotide cap analogue. m7GpppCpG can be used as a chemical tool enabling manufacturing of RNA featuring either cap 0 or cap 1 structures.
    m7GpppCpG
  • HY-180623
    Avicholic acid
    Avicholic acid is a nucleoside metabolite.
    Avicholic acid
  • HY-152683
    3-(2-Pyridinylmethyl)uridine
    N3-[(Pyrid-2-yl)methyl]uridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    3-(2-Pyridinylmethyl)uridine
  • HY-180764
    cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
    cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol is a nucleoside metabolite.
    cis-3-(Carboxy-ethyl)-3,5-cyclo-hexadiene-1,2-diol
  • HY-178659
    N4-Methyl-CTP
    N4-Methyl-CTP is a monomeric raw material that can be used for nucleic acid synthesis.
    N4-Methyl-CTP
  • HY-W784564
    dITP
    dITP (2'-Deoxyinosine-5'-triphosphate) is a monomeric raw material that can be used for nucleic acid synthesis.
    dITP
  • HY-178575
    CTPαS (Rp isomer)
    CTPαS (Rp isomer) is a monomeric raw material that can be used for nucleic acid synthesis.
    CTPαS (Rp isomer)
  • HY-137658A
    Purine riboside-5'-O-triphosphate sodium
    Purine riboside-5'-O-triphosphate sodium, an active metabolite of Nebularine (HY-103694), acts as an inhibitor of DNA primase ATP and GTP polymerization activities, with IC50 values of 35 µM and 28 µM for the human enzyme, respectively. Purine riboside-5'-O-triphosphate sodium inhibits calmodulin-dependent protein kinase II (CaMKII) with a Ki value of 590 µM.
    Purine riboside-5'-O-triphosphate sodium
  • HY-178555
    EX-A8186
    EX-A8186 is a monomeric raw material that can be used for nucleic acid synthesis.
    EX-A8186
  • HY-16445BR
    CNDAC hydrochloride (Standard)
    Dioscin (Standard) is the analytical standard of Dioscin. This product is intended for research and analytical applications. Dioscin (CCRIS 4123; Collettiside III) is a natural plant-derived steroidal saponin that has good anti-cancer activity against a variety of cancer cells. Dioscin causes DNA damage and induces apoptosis in HeLa and SiHa cells. Dioscin regulates ROS-mediated DNA damage and mitochondrial signaling pathways, exerting anticancer activity.
    CNDAC hydrochloride (Standard)
  • HY-106934AR
    Peldesine dihydrochloride (Standard)
    Peldesine (dihydrochloride) (Standard) is the analytical standard of Peldesine (dihydrochloride). This product is intended for research and analytical applications. Peldesine (BCX 34) dihydrochloride is a potent, competitive, reversible and orally active purine nucleoside phosphorylase (PNP) inhibitor with IC50s of 36 nM, 5 nM, and 32 nM for human, rat, and mouse red blood cell (RBC) PNP, respectively. Peldesine dihydrochloride is also a T-cell proliferation inhibitor with an IC50 of 800 nM. Peldesine dihydrochloride has the potential for cutaneous T-cell lymphoma, psoriasis and HIV infection research.
    Peldesine dihydrochloride (Standard)